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Therapeutics

September 19th, 2009 by admin

Actinomycosis
• Systemic therapy: penicillin or tetracycline in large doses for
3–6 mo
• Wide excision of infected tissue
Acute Herpetic Gingivostomatitis
• Systemic therapy
• Valacyclovir 500 mg #20; 1 tablet twice daily × 10 d
• Acyclovir 400 mg #50; 1 tablet 5 times daily × 10 d
• Fluids
• Analgesia
Acute Necrotizing Ulcerative Gingivitis
• Débridement of necrotic tissue
• Aggressive oral hygiene and plaque control
• Metronidazole 250 mg #40; 1 4 times daily × 10 d
Angioedema
• Systemic therapy
• Antihistamine: diphenhydramine 50 mg capsules #12;
1 every 6 h × 2–3 d
• Doxepin 25 mg tablets #12; 1 every 6 h × 2–3 d
• Prednisone 10 mg tablets #12; 4 tablets daily × 3 d
Aphthous Stomatitis
• See “Recurrent Aphthous Stomatitis.”
Behçet’s Disease
• Treat as for aphthosis (see “Recurrent Aphthous Stomatitis”).
• Refer to a dermatologist, a rheumatologist, or an ophthalmologist,
depending on organ involvement, for ongoing care,
which may include systemic immunosuppressive and/or
anti-inflammatory drugs.
Candidiasis
• Identify and correct provocative factors.
• Topical therapy
• Nystatin oral suspension (100,000 units/mL); rinse 5 mL
and swallow 4 times/d
• Clotrimazole (Lotrimin) solution 1%; rinse 5 mL and
swallow 4 times/d
Clotrimazole troches (Mycelex) 10 mg; dissolve 1 troche in
mouth 5 times/d
• Clotrimazole vaginal tablets 1/2 of 500 mg tablet dissolved
in mouth bid
• Systemic therapy
• Fluconazole (Diflucan) 100 mg #15; 2 tablets on the first day,
1 tablet days 2–7, 1 tablet every other day for days 8–21
• Ketoconazole (Nizoral) 200 mg #21; 1 tablet every day with
breakfast × 21 d
• Itraconazole (Sporanox) 200 mg #21; 1 tablet every day
with breakfast × 21 d
• May use shorter duration for less severe infections

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